Negative Effects of Nitrogen Dioxide May be due to Testosterone


Copyright 2004, James Michael Howard, Fayetteville, Arkansas, U.S.A.


Nitrogen dioxide is a “pollutant” that is created by burning fuels.  The main sources are power plants and motor vehicles.  It is known to cause problems for people including increased susceptibility to respiratory infections, snoring, lung problems, etc.  I suggest nitrogen dioxide may cause its problems because nitrogen dioxide may increase testosterone in humans as it does in rats (below).  Increased testosterone may be involved in a number of diseases and mortality.


In rats, nitrogen dioxide increases testosterone (Environ Health Perspect 2001; 109: 111-9 and ibid 1999; 107: 539-44).



This is from the Journal of the American Medical Association:


Ozone and Short-term Mortality in 95 US Urban Communities, 1987-2000

Michelle L. Bell, PhD; Aidan McDermott, PhD; Scott L. Zeger, PhD; Jonathan M. Samet, MD; Francesca Dominici, PhD

JAMA. 2004;292:2372-2378.

Context  Ozone has been associated with various adverse health effects, including increased rates of hospital admissions and exacerbation of respiratory illnesses. Although numerous time-series studies have estimated associations between day-to-day variation in ozone levels and mortality counts, results have been inconclusive.

Objective  To investigate whether short-term (daily and weekly) exposure to ambient ozone is associated with mortality in the United States.

Design and Setting  Using analytical methods and databases developed for the National Morbidity, Mortality, and Air Pollution Study, we estimated a national average relative rate of mortality associated with short-term exposure to ambient ozone for 95 large US urban communities from 1987-2000. We used distributed-lag models for estimating community-specific relative rates of mortality adjusted for time-varying confounders (particulate matter, weather, seasonality, and long-term trends) and hierarchical models for combining relative rates across communities to estimate a national average relative rate, taking into account spatial heterogeneity.

Main Outcome Measure  Daily counts of total non–injury-related mortality and cardiovascular and respiratory mortality in 95 large US communities during a 14-year period.

Results  A 10-ppb increase in the previous week’s ozone was associated with a 0.52% increase in daily mortality (95% posterior interval [PI], 0.27%-0.77%) and a 0.64% increase in cardiovascular and respiratory mortality (95% PI, 0.31%-0.98%). Effect estimates for aggregate ozone during the previous week were larger than for models considering only a single day’s exposure. Results were robust to adjustment for particulate matter, weather, seasonality, and long-term trends.

Conclusions  These results indicate a statistically significant association between short-term changes in ozone and mortality on average for 95 large US urban communities, which include about 40% of the total US population. The findings indicate that this widespread pollutant adversely affects public health.