Testosterone Treatment and Nausea
Copyright 2017, James Michael Howard, Fayetteville, Arkansas, 72701
It is my hypothesis that human evolution is driven by increases in testosterone. “Androgens in Human Evolution,” Rivista di Biologia / Biology Forum 2001; 94: 345-362. If your library does not subscribe to “Rivista … ,” you may find this at: http://anthropogeny.com/Androgens%20in%20Human%20Evolution.htm . This is derived from my explanation of mammalian evolution. “Hormones in Mammalian Evolution,” Rivista di Biologia / Biology Forum 2001; 94: 177-184. If your library does not subscribe to “Rivista … ,” you may find this at: http://anthropogeny.com/Hormones%20in%20Mammalian%20Evolution.htm .
The basis is that testosterone evolved to enhance use of DHEA. Very simply, testosterone directs use of available DHEA to various tissues according to a hierarchy of tissues.
It is my hypothesis that low DHEA results in nausea. “ Possible Explanation of Nausea,” at: http://anthropogeny.com/dheanausea.htm .
I suggest that testosterone treatment reduces available DHEA because the testosterone directs available DHEA to certain tissues at the expense of other uses. In an individual of lower DHEA, for example, an older individual, this would suddenly reduce DHEA and cause nausea.
For demonstrative purposes, it is my hypothesis that evolution selected dehydroepiandrosterone (DHEA) because it optimizes replication and transcription of DNA, that is, genes. Therefore, DHEA levels affect all tissues and all tissues compete for available DHEA, especially the brain. (I think evolutionary selection of DHEA produced mammalia. “Hormones in Mammalian Evolution,” Rivista di Biologia / Biology Forum 2001; 94: 177-184). DHEA naturally begins to decline around the ages of twenty to twenty-five, reaching very low levels in old age. When DHEA is low or decreasing, all tissues are adversely affected. I suggest the “cannabinoid receptor 1” may be the DHEA receptor along with the androgen receptor.
If an individual is infected, DHEA levels will be reduced because of use of DHEA by the immune system; many infections cause nausea. Since I mention cannabinoids, just above, cannabinoids work by competition with DHEA for its receptors, which would free up available DHEA, that is, increase DHEA which would reduce nausea.
I suggest testosterone treatment should begin with DHEA treatment. This may explain why treatment with testosterone has been found to produce adverse effects such as nausea, and other symptoms caused by reduced DHEA.